“Masters of Sex” is a new television series on Showtime that tells the story of Dr. William Masters (Michael Sheen) and his secretary, Virginia Johnson's (Lizzy Caplan) research, answering questions and busting sex myths. The history of sexual research is interwoven into a riveting plot that creatively display how answers to sexual questions were discovered during this time period in the late '50s.
Masters is a busy man; he is a doctor, husband and researcher. Even though he specializes in treating infertile women, his wife, Libby (Caitlin Fitzgerald), cannot conceive a baby. Also, he feels extremely passionate about this research that his boss and head of the university, Barton Scully (Beau Bridges) continues to be shut down.
Johnson is also a busy woman. After two failed marriages, she is raising her two children on her own. Even though she enrolled at the university in the sociological department and has a job working with Masters, her life is still challenging because she needs to take care of her kids and aid Masters in his research. Another doctor she works with, Dr. Ethan Haas (Nicholas D’Agosto), pursues her, adding to her complicated life.
New ideas and controversial topics are honestly displayed in "Masters of Sex," as it introduces viewers to difficult decisions and confusing times. Some scenes are explicit and erotic, with sex and blatant nudity. The sex is for pleasure, research and childbearing purposes.
Infertility and prostitution are recurring topics in this series. Infertility is primarily exhibited through Masters’ wife, who has been trying to have a baby for two years. Struggles with prostitution are evident when the viewers are introduced to a prostitute, Betty DiMello (Annaleigh Ashford), and her roommates.
Infidelity and sexual tensions arise as characters find unwanted or unnecessary attraction toward other characters, both during research and in their personal lives. 
Masters and Johnson's research was about understanding human sexuality during a time when sex was not openly discussed. Their research not only clarified myths about sex, but it also answered questions about what happens to the body during sex.
Catch “Masters of Sex” on Sundays at 10 p.m. on Showtime.